X-Ray Diffraction Unit
Dr. Jordi Benet-Buchholz
Dr. Eduardo Escudero
Dr. Marta Martínez
In the following charts you can see the evolution of the Unit in terms of samples managed in both techniques, single crystal and powder diffraction:
Single Crystal and Power Diffraction
In 2020 a new Powder X-Ray Diffractometer, Empyrean by Malvern Panalytical, was installed. It’s a variable system, which allows to measure PXRD patterns in transmission (Kα1) and reflection Kα). Additionally, it can measure GID, Reflectometry, SAXS, capillaries and it is equipped with an oven/humidity chamber. This new acquisition was possible thanks to the 2018 Ministerio call for equipment acquisition.
First measurements were performed at the ILL (Grenoble) using Neutron radiation on the compound S-Naproxene +-Tramadol. The purpose of this project was that of exploring hydrogen bonds in co-crystal and salt interactions of pharmaceutical salts/co-crystals formed by two APIs, which were crystallized with the CO2 laser at the X-ray Diffraction Unit. Due to the COVID-19 restrictions the measurements were performed remotely.
The Unit participated in the project “Factoría de Cristalización: Red temática para el avance de la cristalografía aplicada” (Ref. RED2018-102574-T) which provided budget (€14,000) for traveling and scientific collaborations in the frame of the Spanish network of crystallographers.