ERC awarded Advanced Grant to Martin’s catalytic orchestra

Prof. Rubén Martín, ICIQ group leader and ICREA professor, was awarded a European Research Council (ERC) Advanced Grant to develop the project NOVOFLAT: “Escaping from Flatland by ‘de novo’ Catalytic Decarboxylation Techniques.”

With a 2,5M € budget and 5-year scope, the project aims at creating a new and general method to forge saturated carbon-carbon bonds through a triple catalytic cascade. If the daring approach is successful, as preliminary results suggest, it will provide an “à la carte” tool for chemists that will streamline the preparation of new molecules of interest for lead generation in drug discovery approaches.

Better together

Like an orchestra conductor, Martín’s project will harness the power of three catalysts to cooperatively achieve unprecedented transformations. “NOVOFLAT is a new way of understanding catalysis for forging carbon-carbon bonds with improved flexibility, practicality, predictable site-selectivity, preparative utility, stereocontrol and nearly zero waste generation,” explained the scientist.

The triple catalytic cascade will trigger a decarboxylation event while controlling and modulating both site-selectivity and stereocontrol when forging the targeted carbon-carbon bond – and with CO₂ as the sole byproduct. Current strategies towards the same goal typically make use of pre-functionalized precursors, which create associated waste products difficult to dispose of or re-use. “Although formally, CO₂ is a waste product, it has enormous synthetic potential – and the group knows how to take advantage of it,” quipped Martín, who hints the CO₂ produced through this method in industrial plants could easily be re-used in situ after its generated.

By tweaking the catalysts, pharmaceutical researchers will be able to easily identify new drug candidates or modify existing ones at will in a practical and modular approach. In this manner, such an approach will provide a new strategy to assemble sp3-hybridized carbon atoms, a dire necessity in the drug discovery pipeline. This way, NOVOFLAT will offer a new platform of the utmost synthetic relevance for the practice of organic synthesis.

“The project is a result of the maturity acquired during the last ten years as a group leader at ICIQ. In addition, the project is a collective effort and a direct recognition of the contributions that my group has made through the years. Without their dedication and enthusiasm, I wouldn’t be here today,” thanked the scientist.

With an overall budget of 450 M€, the ERC selected 185 daring projects to be funded and explore the most venturous research ideas. ERC Advanced Grants are designed to support excellent scientists in any field at the career stage at which they have already established themselves as research leaders with a recognised track record of research achievements in the last ten years. In the 2020 call, 185 established research leaders were awarded an Advanced Grant. Of a total of 1881 proposals, making the success rate for this call 9,8 %. In the domain of Physical Sciences and Engineering, 839 proposals were submitted and only 82 projects, NOVOFLAT among them, received funding. With the new project, ICIQ added a total of 21 ERC projects.